Publications

#: Equal contribution, *: Corresponding author, Bold: Park lab members

• Decoding Tumor Microenvironment Secretomes in Living Animal via A Proximity Labeling Strategy
  Ala Jo#, Sujin Lee#, Soyoung Yoon, Ru Yi, Hankum Park*, Jae-Hyun Lee*
  manuscript in preparation

• Development of a Photocaged CLIPTAC for Spatiotemporal Control of Protein Degradation
  Jaeseok Lee#, Junhyeong Yim#, Solbi Kim#, Junyoung Park, Soyoung Yoon, Sunbin Jung, Ala Jo*, Hankum Park*, Jongmin Park*
  submitted

• Heteroaryl Azides as Photocrosslinking Groups for Target Identification
  Gopathi Ramu, Solbi Kim, Junyoung Park, Hana Cho, Hankum Park, Youngjun Lee*, Junhyeong Yim*, Jongmin Park*
  submitted

• Post-translational Chemical Modification of E3 Ligase for Efficient Targeted Protein Degradation
  Eunbin Park#, Jinjoo Jung#, Gangasani Jagadeesh Kumar, Solbi Kim, Jinyong Lee, Soyoung Yoon, Junhyeong Yim, Hankum Park*, Jongmin Park*
  under revision

• Sympathetic dysregulation exacerbates MRONJ via neuro-skeletal axis
  Kyeongho Lee#, Hana Cho#, Hyun Hwang, June Yeon Kim, Soyoung Yoon, Sunbin Jung, Sung-Jin Kim*, Hankum Park*, Jin-Woo Kim*
  Exp. Mol. Med., 2026 (accepted)

• Discovery of a KLHL41 Ligand for Muscle Specific Protein Degradation
  Junhyeong Yim, Jaeseok Lee, Solbi Kim, Ji-Eun Choi, Soyoung Yoon, Hana Cho, Sunbin Jung, Hankum Park*, Juyong Lee*, and Jongmin Park*
  Nat. Commun., 2026, 17 (1), 4551.

• Discovery of a New Tetrahydroquinoline-Based Chemotype for STING Inhibition with In Vivo Efficacy against Acute Kidney Injury
  So Hyeon Jeong#, Ji Hun Wi#, Jiyoon Park, Yeseul Kim, Jinhee Mun, Hayeon Kim, Joo-Youn Lee, Soyoung Yoon, Hankum Park, Gyu Yong Song, Cheulhee Jung, Sanghee Lee*, Hyejin Kim*
  J. Med. Chem, 2026, 69 (9), 11044-11071.

• Investigation of Proteome-Tetrazine Reactivity for a Highly Selective Tetrazine Ligation in Live Cells
  Junyoung Park, Juhee Hahm, Junhyeong Yim, Hyelim Lee, Hwan Min Hwang, Soyeon Lee, Ju-Young Park, Arun Velladurai, Jagadeesh Kumar Ganggasani, Hana Cho, Hankum Park, Minju Lee, Jeehee Lee, Hyunuk Eom, Woon Ju Song, Sanghee Lee*, Eunha Kim*, and Jongmin Park*
  ACS Cent. Sci., 2025, 11 (6), 878-889.

• Pathological implications of Porphyromonas gingivalis in Alzheimer’s disease and therapeutic potential of gingipain inhibitors
  Sunbin Jung, Hankum Park*
  Oral Biol. Res., 2025, 49 (1).

• Systematic analysis of nonprogrammed frameshift suppression in E. coli via translational tiling proteomics.
  Benjamin L. Springstein, Joao A. Paulo, Hankum Park, Kemardo Henry, Eleanor Fleming, Zoe Feder, J. Wade Harper*, Ann Hochschild*
  Proc. Natl. Acad. Sci. USA 2024, 121 (6), e2317453121.

• Phenotype-based screening rediscovered benzopyran-embedded microtubule inhibitors as anti-neuroinflammatory agents by modulating the tubulin–p65 interaction.
  Junhyeong Yim, Jaeseok Lee, Sihyeong Yi, Ja Young Koo, Sangmi Oh, Hankum Park, Seong Soon Kim, Myung Ae Bae, Jongmin Park*, Seung Bum Park*
  Exp. Mol. Med. 2022, 54 (12), 2200-2209.

• Spatial Snapshots of Amyloid Precursor Protein Intramembrane Processing via Early Endosome Proteomics.
  Hankum Park, Frances V. Hundley, Qing Yu, Katherine A. Overmyer, Dain R. Brademan, Lia Serrano, Joao A. Paulo, Julia C. Paoli, Sharan Swarup, Joshua J. Coon, Steven P. Gygi, J. Wade Harper*
  Nat. Commun. 2022, 13 (1).

[Earlier Publications]

• Recent advances in identifying protein targets in drug discovery
  Jaeyoung Ha#, Hankum Park#, Jongmin Park*, Seung Bum Park*
  Cell Chem. Biol. 2021, 28 (3), 394-423.

• Phenotypic discovery of an anti-virulence agent against Vibrio vulnificus via modulation of quorum-sensing regulator SmcR
  Seung Min Kim#, Jongmin Park#, Myun Soo Kim, Heebum Song, Ala Jo, Hankum Park, Tae Sung Kim, Sang Ho Choi*, Seung Bum Park*
  ACS Infect. Dis. 2020, 6 (11), 3076-3082.

• Phenotype-based discovery of a HeLa-specific cytotoxic molecule that downregulates HPV-mediated signaling pathways via oxidative damage
  Sanghee Lee#, Wansang Cho#, Sungyoul Hong, Sihyeong Yi, Heejun Kim, Soo Yeon Baek, Hankum Park, Jinjoo Jung, Young Kee Shin, Seung Bum Park*
  Org. Biomol. Chem. 2019, 17 (31), 7388-7397.

• Label-free target identification in drug discovery via phenotypic screening
  Hankum Park, Jaeyoung Ha, Seung Bum Park*
  Curr. Opin. Chem. Biol. 2019, 50, 66-72.

• Label-free target identification reveals oxidative DNA damage as the mechanism of selective cytotoxic agent (Selected as the Front Cover Article)
  Hankum Park, Seung Bum Park*
  Chem. Sci. 2019, 10 (12), 3449-3458.

• Label-free target identification using in-gel fluorescence difference via thermal stability shift
  Hankum Park, Jaeyoung Ha, Ja Young Koo, Jongmin Park, Seung Bum Park*
  Chem. Sci. 2017, 8 (2), 1127-1133.

• Nonspecific protein labeling of photoaffinity linkers correlates with their molecular shapes in living cells
  Hankum Park#, Ja Young Koo#, Yellamelli V. V. Srikanth, Sangmi Oh, Jiyoon Lee, Jongmin Park*, Seung Bum Park*
  Chem. Commun. 2016, 52 (34), 5828-5831.

• Discovery of a small-molecule inhibitor of protein–microRNA interaction using binding assay with a site-specifically labeled Lin28
  Donghyun Lim, Wan Gi Byun, Ja Young Koo, Hankum Park, Seung Bum Park*
  J. Am. Chem. Soc. 2016, 138 (41), 13630-13638.